An error occurred when performing a file operation WRITE on file C:\Inetpub\wwwroot\...\fusebuilder\app_globals.cfm. The cause of this exception was: java.io.FileNotFoundException: C:\Inetpub\wwwroot\...\fusebuilder\app_globals.cfm (Access is denied).

If you encounter this problem, it's quite possible that the webserver FuseBuilder is hosted on does not have write permissions to the directory, not in the ColdFusion Administrator, but in the server itself. Each server has a different way of handling it, but the ColdFusion server has to have User access to the directory where FuseBuilder is hosted. If the directory or drive is set as "read-only", FuseBuilder won't be able to function.